研究業績 Publications

(Updated on 2018. 4.11.)


英文原著:Original research papers

  1. Matsuda S, Yasukawa T, Sakaguchi S, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D. (2018) Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA. Sci Rep 8: 5801.

  2. Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T.(2018)Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With type 2 Diabetes: the Fukuoka Diabetes Registry. Diabetes Care.doi: 10.2337/dc17-2004. [Epub ahead of print]


英文原著:Original research papers

  1. Mezuki S, Fukuda K, Matsushita T, Fukushima Y, Matsuo R, Goto Y-I, Yasukawa T, Uchiumi T, Kang D, Kitazono T, Ago T. (2017) Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report. BMC Neurol. 17(1):217.

  2. Matsumoto T, Uchiumi T, Monji K, Yagi M, Setoyama D, Amamoto R, Matsushima Y, Shiota M, Eto M, Kang D (2017) Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity. Oncogenesis 6:3.

  3. Yagi M, Uchiumi T, Sagata N, Setoyama D, Amamoto R, Matsushima Y, Kang D. (2017) Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration. Sci Rep. 7(1):15131.

  4. Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T. (2017) Serum adiponectin predicts fracture risk in individuals with type 2 diabetes: the Fukuoka Diabetes Registry. Diabetologia. [Epub ahead of print]

  5. Fakruddin M, Wei FY, Emura S, Matsuda S, Yasukawa T, Kang D, Tomizawa K. (2017) Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species. Nucleic Acids Res. [Epub ahead of print]

  6. Sagata N, Kato TA, Kano SI, Ohgidani M, Shimokawa N, Sato-Kasai M, Hayakawa K, Kuwano N, Wilson AM, Ishizuka K, Kato S, Nakahara T, Nakahara-Kido M, Setoyama D, Sakai Y, Ohga S, Furue M, Sawa A, Kanba S. (2017) Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study. Sci Rep.7(1):13905.

  7. Feichtinger RG, Oláhová M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Jourdain AA, Thompson K, D'Souza AR, Kopajtich R, Alston CL, Koch J, Sperl W, Mastantuono E, Strom TM, Wortmann SB, Meitinger T, Pierre G, Chinnery PF, Chrzanowska-Lightowlers ZM, Lightowlers RN, DiMauro S, Calvo SE, Mootha VK, Moggio M, Sciacco M, Comi GP, Ronchi D, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H. (2017) Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies. Am. J. Hum. Genet. 101(4):525-538.

  8. Matsushima Y, Hirofuji Y, Aihara M, Yue S, Uchiumi T, Kaguni LS, Kang D. (2017) Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation. Sci Rep. 7(1):8315.

  9. Sasaki K, Gotoh K, Miake S, Setoyama D, Yagi M, Igami K, Uchiumi T, Kang D. (2017) p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock. EBioMedicine. (20) 161-172.

  10. Tajiri H, Uruno T, Shirai T, Takaya D, Matsunaga S, Setoyama D, Watanabe M, Kukimoto-Niino M, Oisaki K, Ushijima M, Sanematsu F, Honma T, Terada T, Oki E, Shirasawa S, Maehara Y, Kang D, Côté JF, Yokoyama S, Kanai M, Fukui Y. (2017) Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1. Cell Rep. 19(5):969-980.

  11. Saito T, Uchiumi T, Yagi M, Amamoto R, Setoyama D, Matsushima Y, Kang D. (2017) Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses. Cardiovasc Res. 113(10):1173-1185.

  12. Inoue H, Terachi SI, Uchiumi T, Sato T, Urata M, Ishimura M, Koga Y, Hotta T, Hara T, Kang D, Ohga S. (2017) The clinical presentation and genotpe of protein C deficiency with double mutations of the protein C gene. Pediatr. Blood Cancer 64: e26404.


  1. Uchiumi T., Kang D. (2017) Mitochondrial nucleic acid binding proteins associated with diseases. Front. Biosci. (22): 168-179.

和文総説:Reviews (in Japanese)

  1. 松島 雄一. 「ミトコンドリアマトリックスに局在するプロテアーゼのあらたな機能」化学と生物(日本農芸化学会会誌), 55 (4), 227-229.

  2. 安川 武宏.「ミトコンドリアDNAのユニークな複製メカニズム」 医学のあゆみ(医歯薬出版), 260 (1), 5-10.

  3. 相原 正宗、松島 雄一. 「ミトコンドリアに局在するプロテアーゼのあらたな機能」医学のあゆみ(医歯薬出版), 260 (1), 55-60.


英文原著:Original research papers

1.  Setoyama D, Kato TA, Hashimoto R, Kunugi H, Hattori K, Hayakawa K, Sato-Kasai M, Shimokawa N, Kaneko S, Yoshida S, Goto YI, Yasuda Y, Yamamori H, Ohgidani M, Sagata N, Miura D, Kang D, Kanba S. (2016) Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis.. PLoS One. 11(12):e0165267.

2.  Monji K, Uchiumi T, Hoshizawa S, Yagi M, Matsumoto T, Setoyama D, Matsushima Y, Gotoh K, Amamoto R, Kang D. (2016) Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells. Oncotarget. 7(46): 75221-75234.

3.   Qu J, Yasukawa T, Kang D. (2016) Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells. J. Biochem. 160(1):49-57.

4.   Amamoto R, Uchiumi T, Yagi M, Monji K, Song Y, Oda Y, Shiota M, Yokomizo A, Naito S, Kang D. (2016) The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression. J. Cancer. 7(1):50-9.

5.   Ichiyama M., Ohga S., Ochiai M., Tanaka K., Matsunaga Y., Kusuda T., Inoue H., Ishimura M., Takimoto T., Koga Y., Hotta T., Kang D., Hara T. (2016) Age-specific onset and distribution of the natural anticoagulant deficiency in pediatric thromboembolism. Pediatric Res.79(1-1):81-6.

6.   Ichiyama M, Ohga S, Ochiai M, Fukushima K, Ishimura M, Torio M, Urata M, Hotta T, Kang D, Hara T. (2016) Fetal hydrocephalus and neonatal stroke as the first presentation of protein C deficiency. Brain Dev. 38(2):253-6.

7.   Ando H, Ohagi Y, Yoshida M, Yoshimoto S, Higashi Y, Yagi M, Monji K, Yagi M, Uchiumi T, Kang D, Ichihashi M (2016) Melanin pigment interrupts the fluorescence staining of mitochondria in melanocytes. J Dermatol Sci. 84(3):349-351.

8.   Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. (2016) Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep 6: 37889.

9.  Ochiai M, Matsushita Y, Inoue H, Kusuda T, Kang D, Ichihara K, Nakashima N, Ihara K, Ohga S, Hara T; Kyushu University High-Risk Neonatal Clinical Research Network, Japan. (2016) Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan. PLoS One 11(8): e0161439.

10.  Abe Y, Kubota M, Takazaki S, Ito Y, Yamamoto H, Kang D, Ueda T, Imoto T (2016) Effect on catalysis by replacement of catalytic residue from hen egg white lysozyme to Venerupis philippinarum lysozyme. Protein Sci 25(9): 1637-1647.

11. Ichihara K, Yomamoto Y, Hotta T, Hosogaya S, Miyachi H, Itoh Y, Ishibashi M, Kang D; Committee on Common Reference Intervals, Japan Society of Clinical Chemistry. (2016) Collaborative derivation of reference intervals for major clinical laboratory tests in Japan. Ann Clin Biochem 53(Pt 3): 347-356.

12. Fang J, Yamaza H, Uchiumi T, Hoshino Y, Masuda K, Hirofuji Y, Wagener FA, Kang D, Nonaka K. (2016) Dihydroorotate dehydrogenase depletion hampers mitochondrial function and osteogenic differentiation in osteoblasts. Eur J Oral Sci 124(3):241-245.


英文原著:Original research papers

1.   Arakawa T., Kobayashi-Yurugi T., Alguel Y., Iwanari H., Hatae H., Iwata M., Abe Y., Hino T., Ikeda-Suno C., Kuma H., Kang D., Murata T., Hamakubo T., Cameron A.D., Kobayashi T., Hamasaki N., Iwata S. (2015) Crystal structure of the anion exchanger domain of human erythrocyte band 3. Science. 350(6261):680-4 

2.   Wang L., Ishihara T., Ibayashi Y., Tatsushima K., Setoyama D., Hanada Y., Takeichi Y., Sakamoto S., Yokota S., Mihara K., Kang D., Ishihara N., Takayanagi R., Nomura M. (2015) Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration. Diabetologia. 2015 Oct;58(10):2371-80.

3.   Hirota Y., Yamashita S., Kurihara Y., Jin X., Aihara M., Saigusa T., Kang D., Kanki T. (2015) Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways. Autophagy. 11(2):332-43.

4.   Ikeda M., Ide T., Fujino T., Arai S., Saku K., Kakino T., Tyynismaa H., Yamasaki T., Yamada K., Kang D., Suomalainen A., Sunagawa K. (2015) Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress. PLoS One. 10(3):e0119687.

5.   Sakai C., Yamaguchi S., Sasaki M., Miyamoto Y., Matsushima Y., Goto Y. (2015) ECHS1 mutations cause combined respiratory chain deficiency resulting in Leigh syndrome. Hum Mutat. 36(2):232-239.

6.   Ogawa, E., Furusyo, N., Murata, M., Hayashi, T., Shimizu, M., Mukae, H., Toyoda, K., Hotta, T., Uchiumi, T., Hayashi, J. (2015) Impact of HCV kinetics on treatment outcome differs by the type of real-time HCV assay in NS3/4A protease inhibitor-based triple therapy,」 Antiviral research 12, 35-42.

7.   Mukai, N., Ninomiya, T., Hata, J., Hirakawa, Y., Ikeda, F., Fukuhara, M., Hotta, T., Koga, M., Nakamura, U., Kang, D., Kitazono, T., Kiyohara, Y. (2015) Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study, Cardiovascular Diabetology 14, 84.

8.   Kiyosuke, M., Kibe, Y., Oho, M., Kusaba, K., Shimono, N., Hotta, T., Kang, D., Shobuike, T., Miyamoto, H. (2015) Comparison of Two Types of Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometers for the Identification and Typing of Clostridium difficile. Journal of Medical Microbiology 64, 1144-1150.

9.   Ikeda, K., Ichihara, K., Hashiguchi, T., Hidaka, Y., Kang, D., Maekawa, M., Matsumoto, H., Matsushita, K., Okubo, S., Tsuchiya, T., Furuta, K., Committee for Standardization, T. J. S. o. L. M. J. (2015) Evaluation of the short-term stability of specimens for clinical laboratory testing. Biopreservation and Biobanking 13, 135-143.

10. Ichihara, K., Yamamoto, Y., Hotta, T., Hosogaya, S., Miyachi, H., Itoh, Y., Ishibashi, M., Kang, D. (2015) Collaborative derivation of reference intervals for major clinical laboratory tests in Japan. Annals of Clinical Biochemistry.

11.  Shiota, M., Itsumi, M., Takeuchi, A., Imada, K., Yokomizo, A., Kuruma, H., Inokuchi, J., Tatsugami, K., Uchiumi, T., Oda, Y., Naito, S. (2015) Crosstalk between epithelial-mesenchymal transition and castration resistance mediated by Twist1/AR signaling in prostate cancer. Endocr. Relat. Cancer 22, 889-900.

12.  Shiota, M., Fujimoto, N., Yokomizo, A., Takeuchi, A., Itsumi, M., Inokuchi, J., Tatsugami, K., Uchiumi, T., Naito, S. (2015) SRD5A gene polymorphism in Japanese men predicts prognosis of metastatic prostate cancer with androgen-deprivation therapy. Eur. J. Cancer 51, 1962-1969.

13.  Nakamura, K., Ago, T., Tsuchimoto, A., Noda, N., Nakamura, A., Ninomiya, T., Uchiumi, T., Tsuruya, K., Kamouchi, M., Ooboshi, H., Kitazono, T. (2015) A CADASIL-Like Case with a Novel Noncysteine Mutation of the NOTCH3 Gene and Granular Deposits in the Renal Arterioles. Case Rep. Neurol. Med. 2015, 431-461.

和文原著:Original research papers (in Japanese)

1.        池松秀之, 鄭湧, 白根健次郎, 藤英博, 佐々木裕之, 古賀結, 松本信也, 堀田多恵子, 内海健, 康東天. 「2013/14年流行期に患者より分離されたインフルエンザA/H1N1pdm09,A/H3N2,Bウイルスのノイラミニダーゼ遺伝子と薬剤感受性との関連についての検討,」 福岡医学雑誌 106, 231-239. (2015)

2.         池松秀之, 鄭湧, 白根健次郎, 藤英博, 佐々木裕之, 古賀結, 浦田美秩代, 堀田多恵子, 内海健, 康東天. 「2011/12及び2012/13インフルエンザ流行期に患者より分離されたA/H3N2型ウイルス96株のNA遺伝子配列と薬剤感受性との関連についての検討,」 福岡医学雑誌 106, 16-22. (2015)

3.         康東天. 「これだけは知っておきたい検査のポイント-第9集 臨床検査の標準化 臨床検査値のJCCLS共用基準範囲とその利用,」 Medicina 52, 10-13. (2015)

4.         康東天. 「多施設間の検査データ活用における現状と今後の課題 項目コード(JLAC10)を用いた多施設間検査情報共有のための取り組みと問題点,」 臨床病理 63, 129-132. (2015)

5.         康東天. 「自己免疫性脳炎-抗原・抗体は何をしている? αエノラーゼ 多機能蛋白質αエノラーゼ,」 Clinical Neuroscience 33, 98-101. (2015)


英文原著:Original research papers

1.    Iizuka, Y., Yamashita, K., Sakasegawa, S., Hanada, T., Tani, W., Adachi, H., Haga, R., Yamaguchi, M., Kurotani, W., Sekiguchi, M., Osawa, S., Hosogaya, S., Kang, D., Ueda, S. (2014) Improvement and evaluation of a 1,2-dioleoylglycerol method for measuring pancreatic lipase catalytic activity in serum, Clin. Chem. Lab. Med. 52, e171-173.

2.    Fukuoh, A., Cannino, G., Gerards, M., Buckley, S., Kazancioglu, S., Scialo, F., Lihavainen, E., Ribeiro, A., Dufour, E., Jacobs, H. T. (2014) Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase, Mol. Syst. Biol. 10, 734.

3.    Itsumi, M., Shiota, M., Yokomizo, A., Takeuchi, A., Kashiwagi, E., Dejima, T., Inokuchi, J., Tatsugami, K., Uchiumi, T.Naito, S. (2014) PMA induces androgen receptor downregulation and cellular apoptosis in prostate cancer cells, J. Mol. Endocrinol. 53, 31-41.

4.    Kashiwagi, E., Shiota, M., Yokomizo, A., Inokuchi, J., Uchiumi, T., Naito, S. (2014) EP2 signaling mediates suppressive effects of celecoxib on androgen receptor expression and cell proliferation in prostate cancer, Prostate Cancer Prostatic Dis. 17, 10-17.

5.    Niho, K., Nakasya, A., Ijichi, A., Tsujita, J., Gotoh, K., Shinozaki, H., Matsumoto, M. (2014) A case of bleeding duodenal ulcer with pemphigus vulgaris during steroid therapy, Clin. J. Gastroenterol. 7, 223-227.

6.    Shiota, M., Itsumi, M., Yokomizo, A., Takeuchi, A., Imada, K., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Uchiumi, T., Naito, S. (2014) Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer, The Prostate 74, 829-838.

7.    Shiota, M., Yokomizo, A., Takeuchi, A., Imada, K., Kashiwagi, E., Song, Y., Inokuchi, J., Tatsugami, K., Uchiumi, T. Naito, S. (2014) Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer, Clin. Cancer Res. 20, 951-961.

8.   Shiota, M., Yokomizo, A., Takeuchi, A., Itsumi, M., Imada, K., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Uchiumi, T., Naito, S. (2014) Inhibition of RSK/YB-1 signaling enhances the anti-cancer effect of enzalutamide in prostate cancer, The Prostate 74, 959-969.

9.    Song, Y. H., Shiota, M., Yokomizo, A., Uchiumi, T., Kiyoshima, K., Kuroiwa, K., Oda, Y., Naito, S. (2014) Twist1 and Y-box-binding protein-1 are potential prognostic factors in bladder cancer, Urol. Oncol. 32, 31.e31–31.e37.

10.  Aihara, M., Jin, X., Kurihara, Y., Yoshida, Y., Matsushima, Y., Oku, M., Hirota, Y., Saigusa, T., Aoki, Y., Uchiumi, T., Yamamoto, T., Sakai, Y., Kang, D., Kanki, T. (2014) Tor and the Sin3Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast, J. Cell Sci. 127, 3184-3196.

11.  Unal, S., Gumruk, F., Yigit, S., Tuncer, M., Tavil, B., Cil, O., Takci, S., Urata, M., Hotta, T., Kang, D., Cetin, M. (2014) A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period, Pediatr. Blood Cancer 61, 763-764.

12.  Mukai, N., Yasuda, M., Ninomiya, T., Hata, J., Hirakawa, Y., Ikeda, F., Fukuhara, M., Hotta, T., Koga, M., Nakamura, U., Kang, D., Kitazono, T., Kiyohara, Y. (2014) Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study, Cardiovasc. Diabetol. 13, 45.

13.  Hoshina, T., Nakashima, Y., Sato, D., Nanishi, E., Nishio, H., Nagata, H., Yamamura, K., Doi, T., Shiokawa, Y., Koga, Y., Kang, D., Ohga, S., Hara, T. (2014) Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood, J. Infect. Chemother. 20, 128-130.

14.  Baba, T., Otake, H., Sato, T., Miyabayashi, K., Shishido, Y., Wang, C. Y., Shima, Y., Kimura, H., Yagi, M., Ishihara, Y., Hino, S., Ogawa, H., Nakao, M., Yamazaki, T., Kang, D., Ohkawa, Y., Suyama, M., Chung, B. C., Morohashi, K. (2014) Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, Nat. Commun. 5, 3634.

和文総説:Reviews (in Japanese)

15.  康東天 (2014) 臨床検査の「共用基準範囲とその利用の手引き」の解説, 医薬品医療機器レギュラトリーサイエンス. 45, 762-765.

16.  康東天 (2014) JCCLS共用基準範囲の設定とその利用, 会誌ふくおか(福岡県臨床衛生検査技師会). 10, 18-31.


英文原著:Original research papers

1.    Uchiumi, T., Tanamachi, H., Kuchiwaki, K., Kajita, M., Matsumoto, S., Yagi, M., Kanki, T., and Kang, D. (2013) Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome, Hepatol. Res. 43, 569-575.

2.    Song, Y. H., Shiota, M., Yokomizo, A., Uchiumi, T., Kiyoshima, K., Kuroiwa, K., Oda, Y., and Naito, S. (2013) Twist1 and Y-box-binding protein-1 are potential prognostic factors in bladder cancer. , Urol. Oncol. 32, 31.e31?31.e37.

3.    Nakanishi, N., Fukuoh, A., Kang, D., Iwai, S., and Kuraoka, I. (2013) Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase: implications for bypass RNA synthesis on oxidative DNA lesions, Mutagenesis 28, 117-123.

4.    Matsunaga, Y., Ohga, S., Kinjo, T., Ochiai, M., Ito, N., Doi, T., Kang, D., and Hara, T. (2013) Neonatal asphyxia and renal failure as the presentation of non-inherited protein C deficiency, Journal of Perinatology : official journal of the California Perinatal Association 33, 239-241.

5.    Matsuda, T., Kanki, T., Tanimura, T., Kang, D., and Matsuura, E. T. (2013) Effects of overexpression of mitochondrial transcription factor A on lifespan and oxidative stress response in Drosophila melanogaster, Biochemical and Biophysical Research Communications 430, 717-721.

6.    Kashiwagi, E., Shiota, M., Yokomizo, A., Itsumi, M., Inokuchi, J., Uchiumi, T., and Naito, S. (2013) Prostaglandin receptor EP3 mediates growth inhibitory effect of aspirin through androgen receptor and contributes to castration resistance in prostate cancer cells Endocr. Relat. Cancer 20, 431-441.

7.    Kanki, T., Kurihara, Y., Jin, X., Goda, T., Ono, Y., Aihara, M., Hirota, Y., Saigusa, T., Aoki, Y., Uchiumi, T., and Kang, D. (2013) Casein kinase 2 is essential for mitophagy., EMBO Rep. 14, 788-794.

8.    Itsumi, M., Shiota, M., Yokomizo, A., Kashiwagi, E., Takeuchi, A., Tatsugami, K., Inokuchi, J., Song, Y., Uchiumi, T., and Naito, S. (2013) Human heterochromatin protein 1 Isoforms regulate androgen receptor signaling in prostate cancer J. Mol. Endocrinol. 50, 401-409 

9.    Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Takazaki, S., Yamaza, H., Nonaka, K., and Kang, D. (2013) Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction, Biosci. Rep. 33, 217-227.


10.  Ohga, S., Ishiguro, A., Takahashi, Y., Shima, M., Taki, M., Kaneko, M., Fukushima, K., Kang, D., and Hara, T. (2013) Protein C deficiency as the major cause of thrombophilias in childhood, Pediatrics International : official journal of the Japan Pediatric Society 55, 267-271.

11.  Hirota, Y., Fujimoto, K., and Tanaka, Y. (2013) Rab GTPases in autophagy; Current topic of Rab32 involvement with autophagy., In Tech.


英文原著:Original research papers

1.    Yagi, M., Uchiumi, T., Takazaki, S., Okuno, B., Nomura, M., Yoshida, S., Kanki, T., and Kang, D. (2012) p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability, Nucleic Acids Research 40, 9717-9737.

2.    Wollen Steen, K., Doseth, B., M, P. W., Akbari, M., Kang, D., Falkenberg, M., and Slupphaug, G. (2012) mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored, DNA Repair (Amst) 11, 82-91.

3.    Takazaki, S., Abe, Y., Yamaguchi, T., Yagi, M., Ueda, T., Kang, D., and Hamasaki, N. (2012) Arg 901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding, Biochimica et Biophysica Acta 1818, 658-665.

4.    Shiota, M., Song, Y., Takeuchi, A., Yokomizo, A., Kashiwagi, E., Kuroiwa, K., Tatsugami, K., Uchiumi, T., Oda, Y., and Naito, S. (2012) Antioxidant therapy alleviates oxidative stress by androgen deprivation and prevents conversion from androgen dependent to castration resistant prostate cancer, The Journal of Urology 187, 707-714.

5.    Oba, T., Yasukawa, H., Hoshijima, M., Sasaki, K., Futamata, N., Fukui, D., Mawatari, K., Nagata, T., Kyogoku, S., Ohshima, H., Minami, T., Nakamura, K., Kang, D., Yajima, T., Knowlton, K. U., and Imaizumi, T. (2012) Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction, J. Am. Coll. Cardiol. 59, 838-852.

6.    Morimoto, N., Miyazaki, K., Kurata, T., Ikeda, Y., Matsuura, T., Kang, D., Ide, T., and Abe, K. (2012) Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice, J Neurosci. Res. 90, 1200-1208.

7.    Matsumoto, S., Uchiumi, T., Tanamachi, H., Saito, T., Yagi, M., Takazaki, S., Kanki, T., and Kang, D. (2012) Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA, The Biochemical Journal 443, 573-584.

8.    Matsumoto, S., Uchiumi, T., Saito, T., Yagi, M., Takazaki, S., Kanki, T., and Kang, D. (2012) Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins, Mitochondrion 12, 391-398.

9.    Kurihara, Y., Kanki, T., Aoki, Y., Hirota, Y., Saigusa, T., Uchiumi, T., and Kang, D. (2012) Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast, The Journal of Biological Chemistry 287, 3265-3272.

10.   Kashiwagi, E., Shiota, M., Yokomizo, A., Itsumi, M., Inokuchi, J., Uchiumi, T., and Naito, S. (2012) Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer, The Prostate 72, 741-751.

11.   Fujino, T., Ide, T., Yoshida, M., Onitsuka, K., Tanaka, A., Hata, Y., Nishida, M., Takehara, T., Kanemaru, T., Kitajima, N., Takazaki, S., Kurose, H., Kang, D., and Sunagawa, K. (2012) Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes, Mitochondrion 12, 449-458.

12.   Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., and Kang, D. (2012) Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients, Bioscience Reports 32, 631-639.

和文原著:Original research papers (in Japanese)

13.   飯塚儀明, 谷渉, 足立浩, 山口真里, 黒谷理, 逆瀬川信一, 今村茂行, 植田成, 花田寿郎, 関口光夫, 康東天 (2012) ヒト血清中の膵リパーゼ活性測定の常用基準法候補法, 臨床化学 41, 72-85.


14.   Uchiumi, T., and Kang, D. (2012) The role of TFAM-associated proteins in mitochondrial RNA metabolism, Biochimica et Biophysica Acta 1820, 565-570.

15.   Klionsky, D. J.,…, Kanki, T.,… , and Zuckerbraun, B. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy 8, 445-544.

16.   Kang, D. (2012) Mitochondrial Genomic Disintegrity and Age-Related Diseases, Anti-Aging Medicine 9, 201-206.

17.   Hirota, Y., Kang, D., and Kanki, T. (2012) The physiological role of mitophagy: new insights into phosphorylation events, International Journal of Cell Biology 2012, 354914.

和文総説:Reviews (in Japanese)
18.  康 東天、柳 茂 (2012) 概論-ミトコンドリア応答から見る疾患学. 実験医学, 30, 1376-1383.

19.  康  東天 (2012) TFAMによるミトコンドリアDNAの維持と疾患からの防御. 実験医学, 30, 1396-1401.


英文原著:Original research papers  
Matsumoto, S., Uchiumi, T., Tanamachi, H., Saito, T., Yagi, M., Takazaki, S., Kanki, T., and Kang, D. Ribonucleoprotein Y-box binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA. Biochem J. 2011

Phosphorylation of Ser114 on Atg32 mediates mitophagy.
Aoki, Y., Kanki, T., Hirota, Y., Kurihara, Y., Saigusa, T., Uchiumi, T., and Kang, D.
Mol. Biol. Cell.

Frequent Truncating Mutation of TFAM Induces Mitochondrial DNA Depletion and Apoptotic Resistance in Microsatellite-Unstable Colorectal Cancer.
Guo J, Zheng L, Liu W, Wang X, Wang Z, Wang Z, French AJ, Kang D, Chen L, Thibodeau SN, Liu W.
Cancer Res. 2011 Apr 15;71(8):2978-87.

Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy.
Amamoto R, Yagi M, Song Y, Oda Y, Tsuneyoshi M, Naito S, Yokomizo A, Kuroiwa K, Tokunaga S, Kato S, Hiura H, Samori T, Kang D, Uchiumi T.
Cancer Sci. 2011 Mar;102(3):639-47.

Importance of mitochondrial genome in multiple cellular functions: A central role of TFAM in its maintenance
Dongchon Kang
2011, 69-88 in Cellular and Genetic Practices for Translational Medicine

Mitochondria autophagy in yeast.
Kanki T, Klionsky DJ, Okamoto K.
Antioxid Redox Signal. 2011 May 15;14(10):1989-2001.

和文総説:Reviews (in Japanese)
生化学 第83巻第2号:126-30


英文原著:Original research papers
ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation.
Uchiumi T, Ohgaki K, Yagi M, Aoki Y, Sakai A, Matsumoto S, Kang D.
Nucleic Acids Res. 2010 Sep;38(16):5554-68.

Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation.
Ruhanen H, Borrie S, Szabadkai G, Tyynismaa H, Jones AW, Kang D, Taanman JW, Yasukawa T.
Biochim Biophys Acta. 2010 Aug;1803(8):931-9.

Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors.
Uchida Y, Mochimaru T, Morokuma Y, Kiyosuke M, Fujise M, Eto F, Eriguchi Y, Nagasaki Y, Shimono N, Kang D.
Int J Antimicrob Agents. 2010 May;35(5):444-50.

PLEDs in an infant with congenital protein C deficiency: a case report.
Sekiguchi K, Akiyoshi K, Okazaki N, Yamada H, Suzuki M, Maeda T, Suenobu S, Izumi T, Kang D.
Clin Neurophysiol. 2010 May;121(5):800-1.

Mutation of His 834 in human anion exchanger 1 affects substrate binding.
Takazaki S, Abe Y, Yamaguchi T, Yagi M, Ueda T, Kang D, Hamasaki N.
Biochim Biophys Acta. 2010 May;1798(5):903-8.

Geographic distribution of fluoroquinolone-resistant Escherichia coli strains in Asia.
Uchida Y, Mochimaru T, Morokuma Y, Kiyosuke M, Fujise M, Eto F, Harada Y, Kadowaki M, Shimono N, Kang D.
Int J Antimicrob Agents. 2010 Apr;35(4):387-91.

Helical image reconstruction of the outward-open human erythrocyte band 3 membrane domain in tubular crystals.
Yamaguchi T, Fujii T, Abe Y, Hirai T, Kang D, Namba K, Hamasaki N, Mitsuoka K.
J Struct. Biol. 2010 Mar;169(3):406-12.

Structure of the membrane domain of human erythrocyte anion exchanger 1 revealed by electron crystallography.
Yamaguchi T, Ikeda Y, Abe Y, Kuma H, Kang D, Hamasaki N, Hirai T.
J Mol Biol. 2010 Mar 19;397(1):179-89.

A genomic screen for yeast mutants defective in mitophagy.
Kanki T, Wang K, Klionsky DJ.
Autophagy. 2010 Feb;6(2):278-80.

Nix, a receptor protein for mitophagy in mammals.
Kanki T.
Autophagy. 2010 Apr;6(3):433-5.

The molecular mechanism of mitochondria autophagy in yeast.
Kanki T, Klionsky DJ.
Mol. Microbiol. 2010 Feb;75(4):795-800.

Publications till 2009 will be updated later.